Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

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Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

The protozoan parasite Trypanosoma brucei causes the fatal illness human African trypanosomiasis (HAT). Standard of care medications currently used to treat HAT have severe limitations, and there is a need to find new chemical entities that are active against infections of T. brucei. Following a "drug repurposing" approach, we tested anti-trypanosomal effects of carbazole-derived compounds call...

Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter

Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral dru...

some new leads for human african trypanosomiasis (african sleeping sickness)

Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis

Human African Trypanosomiasis Advait S. Nagle,† Shilpi Khare,† Arun Babu Kumar,‡ Frantisek Supek,† Andriy Buchynskyy,‡ Casey J. N. Mathison,† Naveen Kumar Chennamaneni,‡ Nagendar Pendem,‡ Frederick S. Buckner, Michael H. Gelb,‡,§ and Valentina Molteni*,† †Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States ‡Departments...